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Frequency: Quarterly
ISSN: 1553-3468 (Print)
ISSN: 1558-6332 (Online)
Research Article Open Access

Changes in Prothrombin Time and Platelet Parameters of Mice Treated with Vitamins C and E

Hongwei Li1, Jing Cheng1, Wei Wang1, Xiangcui Chen1, Tongbing Qi1, Xinzhuo Tu1, Jing Zhang1, Weitong Cui1 and Qinglu Wang1
  • 1 Qilu Medical University, China

Abstract

This study aims to elucidate the influence of supplementation with different doses of Vitamin C (VC) and Vitamin E (VE) on Prothrombin Time (PT) in mice; forty eight mice are randomly divided into six treatment groups, which are fed different dose VC and VE except for control Check (CK) for eight weeks. Blood samples are obtained from the mouse canthus to measure PT and platelet parameters. Administration of different doses of VC and VE to mice cause coagulation function damage.

American Journal of Biochemistry and Biotechnology
Volume 16 No. 2, 2020, 170-176

DOI: https://doi.org/10.3844/ajbbsp.2020.170.176

Submitted On: 2 January 2020 Published On: 15 April 2020

How to Cite: Li, H., Cheng, J., Wang, W., Chen, X., Qi, T., Tu, X., Zhang, J., Cui, W. & Wang, Q. (2020). Changes in Prothrombin Time and Platelet Parameters of Mice Treated with Vitamins C and E. American Journal of Biochemistry and Biotechnology, 16(2), 170-176. https://doi.org/10.3844/ajbbsp.2020.170.176

Open AccessCopyright: © 2020 Hongwei Li, Jing Cheng, Wei Wang, Xiangcui Chen, Tongbing Qi, Xinzhuo Tu, Jing Zhang, Weitong Cui and Qinglu Wang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Vitamin C
  • Vitamin E
  • Prothrombin Time
  • Platelet Parameters