Impact of Vitamin B17 Against Growth of Colitis Bearing Mice Induced Variations in Colon Structure, AFP, CEA and PCNA Immunoreactivity
- 1 Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Egypt
- 2 Department of Zoology, Faculty of Science, Tanta University, Egypt
- 3 Medical Laboratory Science, Fakeeh College for Medical Science, Jeddah 21461, Saudi Arabia
Abstract
Colitis alludes to inflammation of the internal coating of the colon that accompanied clinically through abdominal pains, diarrhea, weight loss, nausea. Current study aimed to study the impact of vitamin B17 against growth of colitis bearing mice induced variations in colon structure, AFP, CEA and PCNA immune reactivity. Forty female Swiss albino mice separated into 4 groups (Control, vitamin B17, colitis and post treated colitis with vitamin B17 groups). Our results revealed significant increase in serum AFP, CEA, colon injury and PCNA expressions. In contrast; post treated colitis with vitamin B17 improved the colon functions and structure, inhibit the proliferations, AFP and CEA. If established in human beings, these outcomes could recommend that; vitamin B17 can be utilized as an adjuvant treatment with chemotherapy drugs.
DOI: https://doi.org/10.3844/ojbsci.2021.228.234
Copyright: © 2021 Gihan Hosny Abd Elsamie, Sabah Gaber El-Banna, Ehab Tousson, Shatha Ghazi Felemban and Mohanad Salam Hussein. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Colitis
- Vitamin B17
- Mice
- Tumor Markers
- PCNA Expressions